Third-party APIs often have rate limits, inconsistent data formats, authentication complexities, and unexpected downtime. Ensuring proper error handling, API request throttling, and caching mechanisms is crucial to avoid failures. OAuth authentication, API versioning, and monitoring API performance prevent disruptions. Dot Net Development should use RESTful best practices, implement retry logic, and design APIs with graceful degradation to maintain reliability. Testing APIs for edge cases, handling timeouts, and logging API responses ensures smooth integration. Utilizing Azure API Management, Swagger, and Postman simplifies API testing and monitoring.